Bromination ofΔ1 Olefins with N-Bromosuccinimide

Substrate Directed Regioselective Monobromination of Aralkyl Ketones Using N-Bromosuccinimide Catalysed by Active Aluminium Oxide: α-Bromination versus Ring Bromination

Bromination of aralkyl ketones using N-bromosuccinimide in presence of active Al2O3 provided either α -monobrominated products in methanol at reflux or mononuclear brominated products in acetonitrile at reflux temperature with excellent isolated yields depending on the nature of substrate employed. The α -bromination was an exclusive process when aralkyl ketones containing moderate activating/d...

Chemical modification of ribonucleic acid polymerase with N-bromosuccinimide.

The mechanism of specific interaction between a protein and a nucleic acid is thought to reside partially in the arrangement and types of amino acid present in the protein. Attempts have been made to assign specific roles in this interaction to certain amino acids, for example, tryptophan and tyrosine are thought to be involved in unwinding the double helix of DNA (Brun et al., 1975), and in se...

Flow injection chemiluminescence determination of N-bromosuccinimide and N-chlorosuccinimide.

Regioselective bromination of fused heterocyclic N-oxides.

A mild method for the regioselective C2-bromination of fused azine N-oxides is presented, employing tosic anhydride as the activator and tetra-n-butylammonium bromide as the nucleophilic bromide source. The C2-brominated compounds are produced in moderate to excellent yields and with excellent regioselectivity in most cases. The potential extension of this method to other halogens, effecting C2...

Investigation of the Early Steps in Electrophilic Bromination through the Study of the Reaction with Sterically Encumbered Olefins

The electrophilic bromination of an alkene is probably the quintessential reaction of the double bond and is portrayed in undergraduate textbooks as being a wellunderstood process adhering to the generalized mechanism depicted in Scheme 1.1,2 For alkenes that do not form a highly stabilized â-bromocarbocation, the reaction invariably proceeds with the initial instantaneous formation of an olefi...